What We Do

AOTI is dedicated to providing Advanced Wound Care products that utilize our patented non-invasive Topical Wound Oxygen (TWO2) therapy. Our innovative products can help close all wound types, and are particularly effective in chronic (diabetic, pressure, and venous ulcers) and acute (post-surgical, cosmetic, and burn) wounds.

TWO2 therapy is unique in that it helps to address the fundamental reasons chronic wounds fail to heal by; reversing wound tissue hypoxia, stimulating the underlying cellular mechanisms needed for tissue regeneration, creating non-contact sequential compression to reduce edema and promote perfusion, and creating an environment that destroys unwanted pathogens and combats infection.

In closing previously unresponsive wounds, TWO2 therapy has significant impact on saving limbs, reducing overall healthcare costs, and greatly improving patients’ quality of life.

The Global Chronic Wound Epidemic
Worldwide expenditures related to treating chronic wounds are estimated to be in excess of $55 Billion annually, making it one of the most costly components of the health care system. Chronic ulcers afflict 33 million people globally and nine million people in the USA, with growing prevalence due to increasing diabetes and obesity rates, as well as a growing aging population. It is estimated that 25 percent of older adults will suffer from chronic limb ulceration by 2050.


There are currently 2.5 million Americans who suffer from Venous leg ulcers (VLU) that mainly occur on the lower leg and above the ankle and can persist for decades, they are the cause of 70% of all leg ulcerations. They usually affect older people and are more common in women. Estimates place the total costs for treatment of VLUs at 1% of health care budgets in many industrialized countries. The cost to treat an individual VLU have been shown to exceed $132,730 over a 1.5 year period.

About 26 million people in the US are currently diagnosed with diabetes and this number is forecast to increase 165% by 2050. Over 11 million people in the US age 65 and over are diagnosed with diabetes, which represents over 27% of this age group. Currently ranked as the nation’s fifth leading cause of death, diabetes is estimated to cost the US $245 billion annually. This equates to 1 in 10 health care dollars spent treating diabetes and its complications and 1 in 5 health care dollars spent caring for people with diabetes.

Diabetes-related wounds or ulcers are chronic complications of this disease and can even result in amputations. Around 25% of diabetics will develop a foot ulcer in their lifetime, resulting in 4 million diabetic foot ulcer cases annually. The average annual cost of care diabetic patient with a foot ulcer is $56,516, which is 5.4 times higher than for those without. If diabetic foot ulcers do not heal they commonly lead to lower-limb amputations. About 66,000 non-traumatic lower-limb amputations are performed on diabetics annually (180/day). A diabetic-related amputation is being performed every 30 seconds worldwide.

Pressure ulcers afflict over 3 million adults in the US every year. Pressure ulcer treatment and prevention are amongst the greatest challenges facing healthcare facilities and caregivers today, alone adding an estimated burden of an additional 2.2 million Medicare hospital days per year at a cost of treatment ranging from $2,000 to $40,000 per ulcer. Studies indicate that length of stay (LOS) for patients who develop pressure ulcers while in the hospital is 2 to 5 times the typical LOS for patients who do not develop pressure ulcers while in the hospital.