A unique multi-modality therapy
A unique multi-modality therapy
Topical Wound Oxygen (TWO2®) therapy allows for targeted treatment, utilizing cyclical pressurized oxygen applied directly to the wound site. Patients self-administer the therapy in the comfort of their own homes while watching TV or reading a book.
After a healthcare provider prescribes TWO2® therapy for their patient, an AOTI representative brings the equipment to the patient’s home and gives detailed instructions on how to use the equipment. Our representatives and customer service team are available when patients have questions or concerns.
TWO2® therapy is indicated for acute or chronic wounds.*
TWO2® is backed by robust clinical evidence, including both a best-in-class Randomized Controlled Trial and Real-World Evidence studies.
Diabetic Foot Ulcers 1, 2
RANDOMIZED CONTROLLED TRIAL
REAL WORLD EVIDENCE STUDY
REDUCTION in Hospitalizations
REDUCTION in Amputations
Venous Leg Ulcers 3
HIGHER HEALING RATE at 12 weeks
| SOC†
LOWER RECURRENCE RATE at 36 months
| SOC†
FASTER TIME TO HEALING
| SOC†
MRSA ELIMINATION
| SOC†
1. 6X More likely to heal DFUs in 12 weeks, 6X Less likely DFUs recur at 12 months:
Frykberg R, Franks P, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical Topical Wound Oxygen (TWO
2. 88% Reduction in hospitalizations, 71% Reduction in amputations:
Yellin J, et al. Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes. Advances in Wound Care, 2021.
3. 2X Faster VLU healing, 87% Lower VLU recurrence rate at 36 months, Pain score dropped from 8 to 3 in 13 days:
Tawfick WA, Sultan, S. Technical and Clinical Outcome of Topical Wound Oxygen in Comparison to Conventional Compression Dressings in the Management of Refractory Nonhealing Venous Ulcers. Vascular and Endovascular Surgery, 2012.
Recommended Treatment Protocol
The recommended Extremity Chamber treatment is 90 minutes, 4-5 days per week.***
**Prescribers may determine alternative frequency or duration depending on an individual patient’s medical needs
***Treatment Recommendation US only. For outside US indication, reference the International Instructions for Use.
Mechanism of Action
Benefits of Supplemental Oxygen
AMPLIFIES local immune response to fight infection
Upregulation of leukocyte function potentiates both neutrophil effectiveness and any concurrent antibiotic therapy being utilized to treat infected wounds. As bacterial metabolism accelerates, senescent bacteria become more susceptible to these defensive mechanisms. The increased oxygen levels also have a direct bactericidal effect on any anaerobic bacteria present.
STIMULATES neovascularization
An increase in the production of vascular endothelial growth factors (VEGF) results in prolific angiogenesis and new blood vessel growth. Additionally, there is a synergistic effect of oxygen on the reactive oxygen species (ROS) needed for transforming growth factor beta (TGFβ) and platelet-derived growth factor (PGF).
PROMOTES stronger collagen synthesis
TWO2® promotes the synthesis of superior quality triple-helix collagen for improved tensile strength, while healing the wound with ideal histology. This results in little to no scarring and healthy desquamation, reducing the risk of callus formation and recurrence.
Benefits of Cyclical Compression
Reduces edema
Decreases resistance to arterial flow
Aids the passage of nutrients to wounded tissues
Accelerates the elimination of metabolites
Prevents the collapse of tunnels and fistulas, avoiding the formation of abscesses
Improves oxygen diffusion and wound bed perfusion
Stimulates damaged end arteries to promote angiogenesis
Benefits of Humidification
A nebulizer delivers a fine particulate mist to the chamber to create an ideal wound healing environment, which allows for fast epithelial cell migration and faster healing.
Here is what HEALTHCARE PROFESSIONALS have to say:
Dr. Guberman
Podiatric Surgeon
“Mainstay of my practice…most superior system”
Cathy Smith
Nurse Practitioner
“It’s a Win/Win… All the way around”
Reimbursment
In the United States, TWO2 is reimbursed within the Veterans Administration and other government sectors under our awarded Worldwide Federal Supply Schedule Contract, contract number: 36F79719D0186. The Veterans Health Administration is the largest Integrated Health Network in the USA, that serves our 23 million Veteran population, operates 1,400 care sites including 154 hospitals, and treats over 9 million veterans each year. Other federal agencies, such as the Department of Defense, Bureau of Indian Affairs, and Bureau of Prisons are also covered by this contract. Additionally, Topical Oxygen is also reimbursed by New York and other state’s Medicaid programs.
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