CLINICAL EVIDENCE
TWO2 delivers the ability to close chronic non-healing and acute complex wounds, achieving more durable healing and providing significant clinical, quality of life and cost saving benefits.
Diabetic Foot Ulcers
REAL WORLD EVIDENCE STUDY
REDUCTION in Hospitalizations
REAL WORLD EVIDENCE STUDY
REDUCTION in Amputations
RANDOMIZED CONTROLLED TRIAL
Compared to standard of care alone
TWO2’s broad therapeutic benefits are supported by an extensive body of evidence and professional guidance
All Clinical Evidence by Category
for Trauma-Induced Venous Leg Wounds in Patients With Diabetes
TWO® Therapy Demonstrates Clinically Meaningful Long-Term Outcomes Compared to Other Advanced Wound Care Modalities: Real-World Evidence Supported by Mechanistic and RCT Clinical Data
A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers
In Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy
Journal of Diabetes and Its Complications
A Meta-Analysis of Randomized Controlled Trials and Observational Studies
TWO2’s broad therapeutic benefits are supported by the highest-level evidence
Levels of Evidence
