Clinical Evidence

TWO2 delivers the ability to close chronic non-healing and acute complex wounds, achieving more durable healing and providing significant clinical, quality of life and cost saving benefits.

REAL WORLD EVIDENCE STUDY

RANDOMIZED CONTROLLED TRIAL

REDUCTION in Hospitalizations

REDUCTION in Amputations

MORE LIKELY TO HEAL in 12 weeks

LOWER RECURRENCE rate at 12 months

REAL WORLD EVIDENCE STUDY

REDUCTION in Hospitalizations

REDUCTION in Amputations

RANDOMIZED CONTROLLED TRIAL

MORE LIKELY TO HEAL in 12 weeks

LOWER RECURRENCE rate at 12 months

TWO2’s broad therapeutic benefits are supported by an extensive body of evidence and professional guidance

Featured

A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study

Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes

New Evidence-Based Therapies for Complex Diabetic Foot Wounds

Carter – Efficacy of Topical Wound Oxygen Therapy in Healing Chronic DFU – Systematic Review and Met Analysis

Topical oxygen therapy for diabetes-related foot ulcers: A systematic review and meta-analysis

Browse by Category

Role of oxygen in wound healing

The Use of Topical Wound Oxygen (TWO2) for the Treatment of Ischemic, Dehisced Open Partial 4th Ray Amputation with Elevated CRPH Levels and Kidney Disease

Review of Evidence of Topical Oxygen Therapy and Chronic Wounds

The Use of Topical Wound Oxygen (TWO2) in Complicated Acute Venous Embolism and Thrombosis of the Lower Extremity

Role of oxygen in wound healing and infection

TWO2’s broad therapeutic benefits are supported by world class evidence

Levels of Evidence

Scientific Clinical Advisory Board

Andrew Boulton – Chairman

MD, DSc (Hon), FACP, FICP, FRCP

President International Diabetes Federation (IDF). Chair EURADIA: Alliance for European Diabetes Research. Professor of Medicine at University of Manchester. Visiting Professor at University of Miami. Past-President European Association for the Study of Diabetes. Associate editor of Diabetes Care (ADA).

David Armstrong

DPM, PhD, MD

Professor of Surgery at the University of Southern California. Founder and co-chair of the American Limb Preservation Society (ALPS), International Diabetic Foot Conference (DFCON) & Southwestern Academic Limb Salvage Alliance (SALSA).

Robert Frykberg

DPM, MPH, FRSM

Adj. Professor Midwestern University and Hon. Professor NUIG. Former Chair of the Foot Care Council of the American Diabetes Association (ADA) and former Chief of the Podiatry section at the Phoenix VAMC. Past President of the American College of Foot and Ankle Surgeons (ACFAS).

Lee Rogers

DPM, RCPS, FFPM

Chief of Podiatry and Asc. Professor of Orthopedics at University of Texas Health Science Center (UTHSC). President of the American Board of Podiatric Medicine (ABPM). Asc. Editor of the Journal of the American Podiatric Medical Association.

Anil Hingorani

MD

Vascular & Endovascular Surgeon at Vascular Institute of New York and New York University Langone Medical Center. Ast. Professor at Mount Sinai Medical Center and SUNY Downstate in Brooklyn. President of the Eastern Vascular Society.

Dane K. Wukich

MD

Professor and Chair of the Department of Orthopedic Surgery at UT Southwestern. Medical Director of Orthopedic Surgery at UT Southwestern University Hospitals. Board member International Association of Diabetic Foot Surgeons (IADFS)

Christopher Attinger

MD

Professor at MedStar Georgetown University Hospital, Plastic & Reconstructive Surgery Department. Director of the Center for Wound Healing. Chairman of the Diabetic Limb Salvage Conference (DLS).

Loretta Vileikyte

MD, PhD

Senior Lecturer in Medicine at the University of Manchester and Research Associate Professor at the University of Miami. Academic Editor of Medicina.