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AOTI offers single use Topical Wound Oxygen (TWO2) therapy products to allow therapy to be applied effortlessly to patients suffering with wounds at home and across a range of healthcare facilities. TWO2 therapy allows for targeted treatment utilizing cyclical pressurized oxygen applied directly to the wound site. TWO2 therapy delivers the highest Topical Oxygen Therapy (TOT) diffusion pressure gradient available, allowing for more durable healing of previously chronic non-healing and acute complex wounds, providing significant clinical, and quality of life and cost saving benefits.

TWO2 therapy is indicated for any type of acute or chronic wound, including: Diabetic Foot Ulcers (DFU), Venous Leg Ulcers (VLU), pressure ulcers, dehiscences, post surgical and burn wounds. Wounds that are both infected and/or ischemic can be successfully treated with TWO2 therapy, as the therapy helps to correct local tissue hypoxia, as well as the underlying problems caused by peripheral vascular disease, while maintaining an ideal moist wound healing environment.

Controller

When applying TWO2 therapy, there is no need to remove gas permeable dressings or compression bandages, making it convenient to use. The TWO2 therapy extremity system is comprised of three major components: A single use Extremity Chamber, Controller and oxygen source. An oxygen flow rate of 10 lpm is used to cycle the therapy pressure between 10 and 50 mb directly at the wound site, within a sealed and humidified environment, providing an oxygen partial pressure diffusion gradient of close to 800 mmHg. This allows for the maximum penetration of oxygen into the wounded tissue. Simple on-screen step-by-step instructions provide easy direction for patients and caregivers to apply the therapy at home.
The cyclical delivery of the oxygen pressure additionally creates non-contact compression on the limb that reduces peripheral edema and stimulates wound site perfusion. Added humidification helps to maintain an ideal moist wound healing environment. The Extremity Chamber is available in two sizes, large and medium. The larger Extremity Chamber has the ability to fit over the patient’s knee, allowing treatment of larger limbs, and VLUs with either conventional compression dressings (CCD) or UNNA boots, as well as DFUs managed with total contact casts (TCC). In the same way, the medium chamber easily accommodates wounds on the lower two thirds of the leg.

Extremity Chamber

Multi-Patch

The TWO2 therapy Multi-Patch system is comprised of two major components: A single use Multi-Patch chamber and an oxygen source. An oxygen flow rate of ≈ 4 lpm applied into the chamber delivers 30 mb of non-contact pressure directly to the wound site, within a sealed and humidified environment. The resultant oxygen partial pressure diffusion gradient of close to 800 mmHg provides for maximum penetration of oxygen into the wounded tissue, penetrating even into indirect wounds, thereby stimulating healing at the deepest point of injury.

Before initial use, a Wound Care Consultant from AOTI, Inc. will set up the unit and walk those using the device each step on how to use it. Additionally, A dedicated team of customer service associates are here to help.

Each Extremity Chamber session is for 90 minutes, which take place 5 days a week. For the Multi Patch, each session is 60 minutes, 7 days per week. Patients complete their session while enjoying other activities such as reading, watching television, or the like. Pain reduction has often been reported, helping increase compliance by patients.

TWO2 Therapy in Action

It is the only topical oxygen therapy that works in multiple ways

Oxygen

High pressure delivery results in greater tissue diffusion critical to restoring normal wound metabolism, resulting in more effective and durable healing.

Cyclical Compression

Non-contact cyclical compression addresses edema and helps correct for the underlying peripheral vascular disease.

Humidification

Assures an ideal moist wound environment, promoting healthy granulation tissues for faster, more effective and durable healing.

TWO2 therapy is indicated for any type of acute or chronic wound

Wound Sites and Types

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3. Calciphylaxis (Typically Lower Extremities and Trunk)

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2. Sickle Cell (Typically Distal 1/3 of Leg)
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12. Pyoderma Gangrenous (Typically Arms and Legs)
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4. Amputation
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4. Amputation
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5. Ischemia (extremities)
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5. Ischemia (extremities)
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6. Breast Reconstruction
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7. Vascular Intervention/Incision
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8. Burn (Any body surface: Heat, Radiation, Chemical)
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3. Calciphylaxis (Typically Lower Extremities and Trunk)

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8.Burn (Any body surface: Heat, Radiation, Chemical)
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9. Mohs Surgery
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10. Bites (Insect, Spider, Etc. – any body surface)
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11. Frostbite/Raynaud’s (fingers/toes)
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11. Frostbite/Raynaud’s (fingers/toes)
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1. Venous Leg Ulcer – Lower Leg (VLU)
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1. Venous Leg Ulcer – Lower Leg (VLU)
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12. Pyoderma Gangrenous (Typically Arms and Legs)
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13. Flexion Wound
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13. Flexion Wound
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14. Surgical Incision
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15. C Section/Abdominoplasty
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16. Diabetic Foot Ulcer (DFU)
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16. Diabetic Foot Ulcer (DFU)
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1. Occiput

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2. Scapula

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3. Sacrum

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4. Heels

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6. Ischium

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5. Spinous Process
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2. Acromion Process

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3. Elbow

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4. Trochanter

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6. Ischium

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5. Femoral Condyles

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8. Tibial Tuberosity

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9. Malleoli

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7. Heels

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1. Elbow
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2. Cheek
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3. Breast
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5. Iliac Crest

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4. Genitalia
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6. Patella
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7. Toes
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1. Shoulder Blades
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4. Elbows
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5. Buttocks
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8. Ischium
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6. Back of Knees
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7. Heels

Reimbursement

In the United States, TWO2 is reimbursed within the Veterans Administration and other government sectors under our awarded Worldwide Federal Supply Schedule Contract, contract number: 36F79719D0186. The Veterans Health Administration is the largest Integrated Health Network in the USA, that serves our 23 million Veteran population, operates 1,400 care sites including 154 hospitals, and treats over 9 million veterans each year. Other federal agencies, such as the Department of Defense, Bureau of Indian Affairs, and Bureau of Prisons are also covered by this contract. Additionally, Topical Oxygen is also reimbursed by New York State Medicaid.

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