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Galway, Ireland, May 26- AOTI announced today that a new clinical study published in the May issue of European Journal of Vascular and Endovascular Surgery demonstrates superior wound closure rates for patients suffering from refractory venous ulcers treated with its revolutionary TWO2 therapy.

Dr. S. Sultan and colleagues from Western Vascular Institute (WVI), Department of Vascular and Endovascular Surgery, University College Hospital Galway

(UCHG), Ireland conducted a parallel comparative study of 83 patients suffering from Refractory Venous Ulcers (RVU).  The aim of this study was to measure the effect of TWO2 on wound healing, using the primary end-point of the proportion of ulcers healed at 12 weeks. Secondary end-points were time to full healing, percentage of reduction in ulcer size, pain reduction, recurrence rates and Quality-Adjusted Time Spent Without Symptoms of disease and Toxicity of Treatment (Q-TWiST). The study concluded that

“TWO2 is safe and effective in Refractory Venous Ulcers (RVU) management. It has a superior outcome to Conventional Compression Dressings (CCD), through achieving a shorter healing time, alleviating pain, reducing recurrence rates and improving the Q-TWiST. We believe that TWO2 is a valuable tool in the armamentarium of management of patients with RVU, without the risks of full body hyperbaric chambers.”“We are extremely pleased with the results of this study”, stated Mike Griffiths President and CEO of AOTI, “ it clearly demonstrates that TWO2 therapy not only closes difficult non healing wounds but also significantly reduces the associated pain of the wound during the healing process.”

AOTI is founded on a decade of experience in providing innovative solutions to resolve severe and chronic wounds worldwide. Our products reduce healthcare costs and improve the quality of life for patients with these debilitating illnesses. Our patented non-invasive Topical Wound Oxygen (two2) therapy is unsurpassed in fully closings Diabetic, Venous and Pressure ulcers alike. AOTI is a private company based in Galway, Ireland with offices throughout the globe. For more information, see

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