CLINICAL EVIDENCE
TWO2 delivers the ability to close chronic non-healing and acute complex wounds, achieving more durable healing and providing significant clinical, quality of life and cost saving benefits.
Diabetic Foot Ulcers
REAL WORLD EVIDENCE STUDY
REDUCTION in Hospitalizations
REAL WORLD EVIDENCE STUDY
REDUCTION in Amputations
RANDOMIZED CONTROLLED TRIAL
Compared to standard of care alone
TWO2’s broad therapeutic benefits are supported by an extensive body of evidence and professional guidance
Featured Evidence
No results found.
All Clinical Evidence by Category
A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers
In Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy
Journal of Diabetes and Its Complications
A Meta-Analysis of Randomized Controlled Trials and Observational Studies
Systematic Review and Meta-Analysis
No results found.
TWO2’s broad therapeutic benefits are supported by the highest-level evidence
Levels of Evidence
Scientific Clinical Advisory Board
Andrew Boulton – Chairman
MD, DSc (Hon), FACP, FICP, FRCP
President International Diabetes Federation (IDF). Chair EURADIA: Alliance for European Diabetes Research. Professor of Medicine at University of Manchester. Visiting Professor at University of Miami. Past-President European Association for the Study of Diabetes. Associate editor of Diabetes Care (ADA).
David Armstrong
DPM, PhD, MD
Professor of Surgery at the University of Southern California. Founder and co-chair of the American Limb Preservation Society (ALPS), International Diabetic Foot Conference (DFCON) & Southwestern Academic Limb Salvage Alliance (SALSA).
Robert Frykberg
DPM, MPH, FRSM
Adj. Professor Midwestern University and Hon. Professor NUIG. Former Chair of the Foot Care Council of the American Diabetes Association (ADA) and former Chief of the Podiatry section at the Phoenix VAMC. Past President of the American College of Foot and Ankle Surgeons (ACFAS).
Lee Rogers
DPM, RCPS, FFPM
Chief of Podiatry and Asc. Professor of Orthopedics at University of Texas Health Science Center (UTHSC). President of the American Board of Podiatric Medicine (ABPM). Asc. Editor of the Journal of the American Podiatric Medical Association.
Anil Hingorani
MD
Vascular & Endovascular Surgeon at Vascular Institute of New York and New York University Langone Medical Center. Ast. Professor at Mount Sinai Medical Center and SUNY Downstate in Brooklyn. President of the Eastern Vascular Society.
Dane K. Wukich
MD
Professor and Chair of the Department of Orthopedic Surgery at UT Southwestern. Medical Director of Orthopedic Surgery at UT Southwestern University Hospitals. Board member International Association of Diabetic Foot Surgeons (IADFS)
Christopher Attinger
MD
Professor at MedStar Georgetown University Hospital, Plastic & Reconstructive Surgery Department. Director of the Center for Wound Healing. Chairman of the Diabetic Limb Salvage Conference (DLS).
Loretta Vileikyte
MD, PhD
Senior Lecturer in Medicine at the University of Manchester and Research Associate Professor at the University of Miami. Academic Editor of Medicina.