Topical oxygen therapy in the patient of chronic diabetic leg & foot ulcer

Topical oxygen therapy in the patient of chronic diabetic leg & foot ulcer

by | Dec 27, 2022

Diabetes mellitus is a metabolic disorder associated with so many complications including diabetic foot syndrome. International Diabetes Federation (IDF) 2021 data reveals that globally 537 million people are suffering from disease & estimated to reach up to 783 million in 2045. In Indian subcontinent (SEA) about 90 million people in the year 2021 estimated to reach 152 million in the year 2045. [1] Diabetic foot syndrome characterized by infection; soft tissue damage & diabetic foot ulcer (DFU) due to diabetic peripheral neuropathy [2]. The prevalence of DFU in type 2 diabetes is 6.4% globally, with 6.38% in South India, and 14.30% in North India. DFU increases risk for lower extremity amputations [3] Many surgical and non-surgical treatments are available to tackle this problem including wound debridement, skin grafting, revascularization, frequent dressing of the wound site with offloading of foot and ultimately amputation in very severe cases to save the life of patient. Primary factor enhancing wound healing process, is oxygen. Hyperbaric oxygen therapy shown benefits in wound healing with adverse effect oxygen toxicity & barotrauma. Topical oxygen therapy (TOT) are safer alternative. It bypasses oxygen transport system & creating oxygen-rich wound bed environment & improved pH levels, helps to cure infection, enhance wound healing & rate of wound closure in chronic non-healing DFUs [4]

Topical Wound Oxygen Therapy in Worsening Diabetic Foot Ulcers: A Case Report

Topical Wound Oxygen Therapy in Worsening Diabetic Foot Ulcers: A Case Report

by | Dec 27, 2022

Diabetic Foot Ulcers (DFUs) are a frequent complication of diabetes with attendant morbidity and mortality. There is some increasing evidence that supports the use of Topical Oxygen Therapy (TOT) in chronic DFUs when used in combination with standard wound care1. Specifically, Topical Wound Oxygen Therapy (TWO2) applies cyclically pressurized humidified oxygen within a single use extremity chamber connected to an oxygen concentrator2.

Synergistic Effects of Dehydrated Placental Allografts and Topical Wound Oxygen Therapy

Synergistic Effects of Dehydrated Placental Allografts and Topical Wound Oxygen Therapy

by | Nov 1, 2022

Wounds with bone exposure, in immunosuppressed patients after solid organ transplant, or post radiation, pose a significant challenge to heal. Bone exposure usually implies some form of osteomyelitis, which in the setting of immune suppression or radiation induced microvascular damage, usually translates to significant patient morbidity and prolonged healing time. We describe here our experience of healing two extremely challenging wounds, in two patients using a combination of two advanced modalities, designed to overcome these particular patient comorbidities.