FASTER and LASTING Healing with TWO2®

FASTER and LASTING Healing with TWO2®

As your partner in care, we are determined to give you the best quality treatment and help you back to living your life to the fullest.

Topical Wound Oxygen (TWO2®) is a clinically proven therapy for the treatment of chronic and difficult-to-heal wounds. The therapy is a safe, non-invasive treatment option that can be used in the comfort of your own home.

Why Choose TWO2® therapy?

A Unique 3-in-1 Therapy

All wounds need oxygen to heal. Chronic wounds can become hypoxic, or low in oxygen. The Extremity Chamber (or “Boot”) gives the wound the oxygen it needs to heal. At the same time, compression from the Boot improves blood flow to help reduce swelling (edema). Lastly, humidification ensures an ideal wound healing environment.

Convenient & Easy-to-use

TWO2 therapy is designed with the patient in mind. You can use the therapy in your home while watching TV or reading a book. At the start of therapy, an AOTI representative will drop the equipment off at your home and teach you how to begin a therapy session. Our Patient Guide walks you through each of the steps in case you want a reminder after the representative leaves your home. If you have any questions or concerns, our representatives and customer service teams are just a phone call away.

Compatible with dressings and TCCs

You can often wear your usual dressings and/or total contact casts (TCCs) underneath the Extremity Chamber (Boot). Your doctor will tell you if your dressings are compatible with TWO2 therapy or if they must be removed before therapy.

Clinically Proven

  • Faster healing*1,2
  • Reduces wound recurrence rates1,2
  • Prevents amputations and hospitalizations3
  • Reduces pain2

*Compared to Standard of Care. Standard of Care for DFU includes offloading, dressing that provides a moist wound healing environment, exudate management and debridement of necrotic tissue. Standard of Care for VLU includes multi-layer gradient compression dressings, dressings that provide a moist wound healing environment, exudate management and debridement of necrotic tissue.

Chair Vase Dark Skin Medium Boot
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1. 6X More likely to heal DFUs in 12 weeks, 6X Less likely DFUs recur at 12 months:

Frykberg R, Franks P, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical Topical Wound Oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care, 2020.

2. 2X Faster VLU healing, 87% Lower VLU recurrence rate at 36 months, Pain score dropped from 8 to 3 in 13 days:

Tawfick WA, Sultan, S. Technical and Clinical Outcome of Topical Wound Oxygen in Comparison to Conventional Compression Dressings in the Management of Refractory Nonhealing Venous Ulcers. Vascular and Endovascular Surgery, 2012.

3. 88% Reduction in hospitalizations, 71% Reduction in amputations:

Yellin J, et al. Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes. Advances in Wound Care, 2021.

How Do I Get Started?

Talk to your doctor to see if TWO2 is right for you. Before finalizing your treatment plan, you and your provider should check your health insurance to make sure the cost will be covered.

How Do I Get Started?

Talk to your doctor to see if TWO2 is right for you. Before finalizing your treatment plan, you and your provider should check your health insurance to make sure the cost will be covered.

Patients Doctor 1

Getting Started & What to Expect

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Before starting the therapy, you should use the bathroom, eat or grab a snack, and gather anything you want to have near you during therapy—such as a TV remote, a book, your phone, and a glass of water.

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You will need to sit or lie down for the duration of the therapy (60-90 minutes unless your doctor has prescribed otherwise).
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There is NO SMOKING during therapy since oxygen is a fire hazard when near an open flame. Make sure that any fireplaces or candles are not lit in the room you are in. Never use an open flame of any kind during treatment.
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You may leave your wound dressings on, unless your doctor has instructed otherwise. The therapy also works over a total contact cast (TCC).
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You should not feel any pain during the therapy. If you do, it is important that you contact your doctor immediately.

Watch the setup video

PATIENT Testimonials

Extremity Chamber

Need more information?

Our dedicated customer service team is here to help.

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Need more information?

Our dedicated customer service team is here to help.