Clinical Evidence
Clinical Evidence
TWO2 delivers the ability to close chronic non-healing and acute complex wounds, achieving more durable healing and providing significant clinical, quality of life and cost saving benefits.
REAL WORLD EVIDENCE STUDY
RANDOMIZED CONTROLLED TRIAL
0%
REDUCTION in Hospitalizations
0%
REDUCTION in Amputations
*Compared to standard of care alone
REAL WORLD EVIDENCE STUDY
0%
REDUCTION in Hospitalizations
0%
REDUCTION in Amputations
RANDOMIZED CONTROLLED TRIAL
MORE LIKELY TO HEAL in 12 weeks*
LOWER RECURRENCE rate at 12 months*
*Compared to standard of care alone
TWO2’s broad therapeutic benefits are supported by an extensive body of evidence and professional guidance
Featured
![Clinical Evidence 11 ADA Standards of Care](https://aotinc.net/wp-content/uploads/2023/03/ada-img.png)
![Clinical Evidence 12 A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study](https://aotinc.net/wp-content/uploads/2022/01/2-2-TWO2-DFU-RCT-Diabetes-Care-March-2020-W-Editorial-1.jpg)
![Clinical Evidence 13 Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes](https://aotinc.net/wp-content/uploads/2022/01/etic-Foot-Ulcers-Treated-with-Cyclical-Pressurized-Topical-Wound-Oxygen-Therapy-Real-World-Outcomes-1.jpg)
![Clinical Evidence 14 New Evidence-Based Therapies for Complex Diabetic Foot Wounds](https://aotinc.net/wp-content/uploads/2022/04/ADA_complex_foot_wounds_compendium_2022-042122.jpg)
![Clinical Evidence 15 Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis](https://aotinc.net/wp-content/uploads/2023/03/carter-efficacy-of-topical.png)
![Clinical Evidence 16 Topical oxygen therapy for diabetes-related foot ulcers: A systematic review and meta-analysis](https://aotinc.net/wp-content/uploads/2022/01/3-3-Thanigaimani-Topical-oxygen-therapy-for-diabetes-related-foot-ulcers-Systemic-Review-April-2021-1.jpg)
Browse Clinical Evidence by Category
![Clinical Evidence 11 ADA Standards of Care](https://aotinc.net/wp-content/uploads/2023/03/ada-img.png)
![Clinical Evidence 12 A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study](https://aotinc.net/wp-content/uploads/2022/01/2-2-TWO2-DFU-RCT-Diabetes-Care-March-2020-W-Editorial-1.jpg)
![Clinical Evidence 13 Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes](https://aotinc.net/wp-content/uploads/2022/01/etic-Foot-Ulcers-Treated-with-Cyclical-Pressurized-Topical-Wound-Oxygen-Therapy-Real-World-Outcomes-1.jpg)
![Clinical Evidence 15 Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis](https://aotinc.net/wp-content/uploads/2023/03/carter-efficacy-of-topical.png)
![Clinical Evidence 21 Technical and Clinical Outcome of Topical Wound Oxygen in Comparison to Conventional Compression Dressings in the Management of Refractory Nonhealing Venous Ulcers](https://aotinc.net/wp-content/uploads/2022/01/8-4-Tawfick-TWO2-vs-CCD-2012-1.jpg)
![Clinical Evidence 22 Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen](https://aotinc.net/wp-content/uploads/2022/01/9-1-2005-Fries-Mutation-Research-Wound-Healing-in-Pigs-Following-TWO-1.jpg)