Clinical Evidence

TWO2 delivers the ability to close chronic non-healing and acute complex wounds, achieving more durable healing and providing significant clinical, quality of life and cost saving benefits.

REAL WORLD EVIDENCE STUDY

RANDOMIZED CONTROLLED TRIAL

REDUCTION in Hospitalizations

REDUCTION in Amputations

MORE LIKELY TO HEAL in 12 weeks*

LOWER RECURRENCE rate at 12 months*

*Compared to standard of care alone

REAL WORLD EVIDENCE STUDY

REDUCTION in Hospitalizations

REDUCTION in Amputations

RANDOMIZED CONTROLLED TRIAL

MORE LIKELY TO HEAL in 12 weeks*

LOWER RECURRENCE rate at 12 months*

*Compared to standard of care alone

TWO2’s broad therapeutic benefits are supported by an extensive body of evidence and professional guidance

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A Randomized Controlled Trial to Evaluate Different Treatment Regimes with Topical Wound Oxygen (TWO2) on Chronic Wounds

The Use of Topical Wound Oxygen (TWO2) in a Severe Lower Extremity Staph Infection Staus Post Incision and Drainage

TWO2 – Extremity Chamber

The Use of a Human Fibroblast-derived Dermal Substitute with Topical Oxygen in Vascular Compromised Wounds

Does Topical Wound Oxygen (TWO2) Offer an Improved Outcome Over Conventional Compression Dressings (CCD) in the Management of Refractory Venous Ulcers (RVU)? A Parallel Observational Comparative Study

The Use of Topical Wound Oxygen Therapy (TWO2) and Grafix Prime Mesenchyinal Stem Cells for Chronic Venous Stasis Ulcerations

TWO2’s broad therapeutic benefits are supported by world class evidence

Levels of Evidence

Scientific Clinical Advisory Board

Andrew Boulton – Chairman

MD, DSc (Hon), FACP, FICP, FRCP

President International Diabetes Federation (IDF). Chair EURADIA: Alliance for European Diabetes Research. Professor of Medicine at University of Manchester. Visiting Professor at University of Miami. Past-President European Association for the Study of Diabetes. Associate editor of Diabetes Care (ADA).

David Armstrong

DPM, PhD, MD

Professor of Surgery at the University of Southern California. Founder and co-chair of the American Limb Preservation Society (ALPS), International Diabetic Foot Conference (DFCON) & Southwestern Academic Limb Salvage Alliance (SALSA).

Robert Frykberg

DPM, MPH, FRSM

Adj. Professor Midwestern University and Hon. Professor NUIG. Former Chair of the Foot Care Council of the American Diabetes Association (ADA) and former Chief of the Podiatry section at the Phoenix VAMC. Past President of the American College of Foot and Ankle Surgeons (ACFAS).

Lee Rogers

DPM, RCPS, FFPM

Chief of Podiatry and Asc. Professor of Orthopedics at University of Texas Health Science Center (UTHSC). President of the American Board of Podiatric Medicine (ABPM). Asc. Editor of the Journal of the American Podiatric Medical Association.

Anil Hingorani

MD

Vascular & Endovascular Surgeon at Vascular Institute of New York and New York University Langone Medical Center. Ast. Professor at Mount Sinai Medical Center and SUNY Downstate in Brooklyn. President of the Eastern Vascular Society.

Dane K. Wukich

MD

Professor and Chair of the Department of Orthopedic Surgery at UT Southwestern. Medical Director of Orthopedic Surgery at UT Southwestern University Hospitals. Board member International Association of Diabetic Foot Surgeons (IADFS)

Christopher Attinger

MD

Professor at MedStar Georgetown University Hospital, Plastic & Reconstructive Surgery Department. Director of the Center for Wound Healing. Chairman of the Diabetic Limb Salvage Conference (DLS).

Loretta Vileikyte

MD, PhD

Senior Lecturer in Medicine at the University of Manchester and Research Associate Professor at the University of Miami. Academic Editor of Medicina.